Charles A. Blum,Richard Dana Caldwell,Rebecca Casaubon,Jeremy S. Disch,Ryan Michael Fox,Karsten Koppetsch,Pui Yee Ng,Christopher Oalmann,Robert B. Perni,Bruce G. Szczepankiewicz,Brian H. White
申请号：
US14891158
公开号：
US09765075B2
申请日:
2014.05.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
