BLUM CHARLES A,OALMANN CHRISTOPHER,SZCZEPANKIEWICZ BRUCE G,CALDWELL RICHARD DANA,CASAUBON REBECCA,WHITE BRIAN H,PERNI ROBERT B,KOPPETSCH KARSTEN,DISCH JEREMY S,NG PUI YEE,FOX RYAN MICHAEL
申请号：
IN10453/DELNP/2015
公开号：
IN2015DN10453A
申请日:
2015.11.13
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin modulating compounds may be used for increasing the lifespan of a cell and treating and/or preventing a wide variety of diseases and disorders including for example diseases or disorders related to aging or stress diabetes obesity neurodegenerative diseases cardiovascular disease blood clotting disorders inflammation cancer and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin modulating compound in combination with another therapeutic agent.
