Charles A. BLUM,Richard Dana CALDWELL,Rebecca CASAUBON,Jeremy S. DISCH,Ryan Michael FOX,Karsten KOPPETSCH,Pui Yee NG,Christopher OALMANN,Robert B. PERNI,Bruce G. SZCZEPANKIEWICZ,Brian H. WHITE
申请号：
US15669301
公开号：
US20180044338A1
申请日:
2017.08.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
