Method for Isolating The Compound 9 {- (R) - 2 - [(S) - {[(S) - 1 - (isopropoxicarbonil) ethyl] amino}} fenoxifosfinil) methoxy] propyl adenine induced Crystallization using Dynamic resolution with antiviral properties； and Methods for preparing the compounds intermediaries involved in said method.
COLBY, DENISE A.,ROBERTS, BENJAMIN JAMES,SCOTT, ROBERT WILLIAM,MARTINS, ANDREW ANTHONY,WHITE, NICOLE, S.
申请号：
CL2014000827
公开号：
CL2014000827A1
申请日:
2014.04.03
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Methods for isolating 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine (compound 16 ): a method for preparing, in high diastereomeric purity, intermediate compounds 13 and 15: and a method for preparing intermediate compound 12: 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine has anti-viral properties.METODO DE CRISTALIZACION DE ADENINA DIASTEREOMERICAMENTE PURA EN PRESENCIA DE UNA BASE.
