FIELD: chemistry.SUBSTANCE: present invention relates to biochemistry. Disclosed methods of screening the IgG antibody, having high capability to eliminate an antigen in plasma, based on selecting the IgG whose antigen-binding activity at pH 6.7-10.0 is higher than the antigen-binding activity at pH 4.0-6.5. IgG antibodies having a weaker antigen-binding activity at pH inside early endosome than at pH in plasma are capable of repeatedly binding with an antigen, have a longer half-life in plasma and longer periods during which they can bind with an antigen.EFFECT: IgG antibodies obtained using the disclosed method have improved pharmacokinetic and a larger number of times of binding with an antigen in vivo.9 cl, 29 dwg, 17 tbl, 18 exBu buluşun sahipleri, erken endozomal pH seviyesinde antijene bağlanma aktiviteleri plazma pH seviyesindekine kıyasla daha zayıf olan antikorların, tek bir antikor molekülüyle birden çok antijen molekülüne bağlanabildiklerini, plazmada uzun yarı ömürlere sahip olduklarını ve antijene bağlanabilecekleri sürenin daha uzun olduğunu keşfettiler.
