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Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
专利权人:
Tomoyuki Igawa
发明人:
Tomoyuki Igawa,Shinya Ishii,Atsuhiko Maeda,Takashi Nakai
申请号:
US13595139
公开号:
US08623360B2
申请日:
2012.08.27
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
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