Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

MAEDA, Atsuhiko,IGAWA, Tomoyuki,NAKAI, Takashi,ISHII, Shinya

申请号：

AU2020202498

公开号：

AU2020202498A1

申请日:

2020.04.14

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020202498A120200507.pdf#####ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY ABSTRACT 5 The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. 10

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