450 400 350 300 • 250 200 ；2 150 106 50 0. Fig, 18: -4- 4 4= , 2 7 1- 7 O 11 , 8 7- C.7 as) 1. 5 I CJ CJ C.>； CeD a.* at. CID fah COD (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT omit VIII °nolo 1101 IIII iflo oimIE (10) International Publication Number WO 2018/136706 Al (51) International Patent Classification: A61K 31/43 75 (2006.01) A61P 17/18 (2006.01) A61K 31/4745 (2006.01) (21) International Application Number: PCT/US2018/014366 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,219 19 January 2017 (19.01.2017) US (71) Applicant: TWI BIOTECHNOLOGY, INC.； 8F, No.41 Lane 221, Kang Chien Rd., Nei Hu Dist., Taipei, 114 (TW). (72) Inventor； and (71) Applicant US only): BROWN, Carl, Oscar [US/US]； 13034 Alora Point, San Diego, CA 92130 (US). (72) Inventors: TSENG, Po-yuan； 8F, No.41 Lane 221, Kang Chien Rd., Nei Hu Dist., Taipei, 114 (TW). LU, Wei-shu； 8F, No.41 Lane 221, Kang Chien Rd., Nei Hu Dist., Taipei, 114 (TW). LIN, I-yin； 8F, No.41 Lane 221, Kang Chien Rd., Nei Hu Dist., Taipei, 114 (TW). TSAI, Chen-en； 8F, No.41 Lane 221, Kang Chien Rd., Nei Hu Dist., Taipei, 114 (TW). CHEN, Chih-kuang； 8F, No.41 Lane 221, Kang Chien Rd., Nei Hu Dist., Taipei, 114 (TW). (74) Agent: POLYAKOV, Mark, V et al.； Wood, Phillips, Katz, Clark & Mortimer, 500 West Madison Street, Suite 1130, Chicago, IL 60661 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW,
