INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau vitivio VIII 00 los nom 0] mom n (43) International Publication Date 24 January 2019 (24.01.2019) WIP0 I PCT (10) International Publication Number WO 2019/016731 Al (51) International Patent Classification: A61K 36/23 (2006.01) A61P 25/28 (2006.01) A61K 36/258 (2006.01) (21) International Application Number: PCT/IB2018/055348 (22) International Filing Date: Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) in black and white； the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (25) (26) (30) (71) (72) (74) (81) (84) 1-1 18 July 2018 (18.07.2018) English English Filing Language: Publication Language: Priority Data: 62/533,926 18 July 2017 (18.07.2017) US Applicant: SENESCENCE LIFE SCIENCES PTE. LTD. [SG/SG]； 71 UBI Road 1, #08-47, Oxley Bizhub, Sin- gapore 408732 (SG). Inventor: WATSON, Shawn Nathan； 19 Palm Grove Avenue, #03-14, Palm Grove Condominium, Singapore 547315 (SG). Agent: JACOB, Sheena et al.； JurisAsia, LLC, One Raffles Quay, #09-06 North Tower, Singapore 048583 (SG). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regiona
