Shu-Hui Liu,Wei-Hsien Ho,Pavel Strop,Magdalena Grazyna Dorywalska,Arvind Rajpal,David Louis Shelton,Thomas-Toan Tran
申请号：
US15160742
公开号：
US10100114B2
申请日:
2016.05.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
