Liu, Shu-Hui,Ho, Wei-Hsien,Strop, Pavel,Dorywalska, Magdalena Grazyna,Rajpal, Arvind,Shelton, David Louis,Tran, Thomas-Toan
申请号：
AU2012335205
公开号：
AU2012335205A1
申请日:
2012.11.07
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
