The invention aims to solve the problems of securing during drug preparations by dematerializing the manufacturing sheet by a graphical interface combined with a comparative video analysis. This comparison causes the eventual triggering of an appropriate alert with a real-time monitoring and preferably a posteriori control of the preparation. According to the invention, a secure imaging system for drug preparations at a given site (1, 3, 10 to 13) comprises a dynamic graphic interface (21, 27) comprising at least one treatment camera (21; 21a, 21b). ) having a focal length set to the object detection (22, 23, 24) and connected to a digital management unit (25) of the video signals (SV1) from the processing camera (21; 21a, 21b). Said unit (25) has means for comparing stored data of the current preparation from the first images (34) corresponding to the video signals (SV1) and stored prescription preparation steps and means for selecting a prescription according to this comparison. Warning means are activated in case of non-compliance of at least one step of the indexed preparation with the corresponding step of the selected prescription. The invention also relates to a shooting device, an object positioning support and a system comprising the camera and the object positioning support according to the invention.L'invention vise à résoudre les problèmes de sécurisation lors des préparations médicamenteuses en dématérialisant la fiche de fabrication par une interface graphique combinée à une analyse comparative vidéo. Cette comparaison provoque le déclenchement éventuel d'une alerte appropriée avec un suivi en temps réel et de préférence un contrôle a posteriori de la préparation. Selon l'invention, un système d'imagerie sécurisé de préparations médicamenteuses sur un site déterminé (1, 3, 10 à 13) comporte une interface graphique dynamique (21, 27) comprenant au moins une caméra de traitement (21; 21a, 21b) ayant une focale réglée sur la détection d'objets (22, 23, 24