Kai Fan,Zhiquan Zhao,Yong Chen,Chun Zhang,Lin Wang
申请号：
US13391097
公开号：
US20120277154A1
申请日:
2010.03.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided is a homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof, wherein the insulinotropic peptide analogue comprises GLP-1 and Exendin-4. The homodimer of insulinotropic peptide analogues of the invention is made by conjugating two identical insulinotropic peptide analogue molecules at the C-terminal Cys residues via disulfide bond or PEG molecule. The homodimer of insulinotropic peptide analogues of the invention has superior stability and biological activity in vivo, and prolonged half-life in the circulation, and can be used for the preparation of hypoglycemic drugs.
