Yu Seok Youn;Kang Choon Lee;Sung Kwon Lee;Su Young Chae;Won Bae Kim
发明人:
Kang Choon Lee,Su Young Chae,Yu Seok Youn,Won Bae Kim,Sung Kwon Lee
申请号：
US12304121
公开号：
US09321825B2
申请日:
2007.06.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.
