Embodiments described herein relate to a glucose monitoring system having a glucose sensor positioned in contact with interstitial fluid in a body of a user. A transmitter unit is coupled to the glucose sensor and processes data indicative of a plurality of monitored glucose levels from the glucose sensor. A receiver unit receives the processed data from the transmitter unit. The receiver unit comprises a processor and a user interface having a touch-sensitive display to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displaying the plurality of monitored glucose levels, a second panel simultaneously displaying a current glucose level and a glucose trend indicator, and a third panel displays status information of a plurality of components of the system. When an alarm condition is detected, the display renders the alert screen in place of one of the first panel, the second panel, or the third panel. The alert screen displays information corresponding to the detected alarm condition. The display affects a further output corresponding to the detected condition in response to user actuation of a portion of the display.