WAGNER, ROLF,TUFANO, MICHAEL D.,STEWART, KENT D.,ROCKWAY, TODD W.,RANDOLPH, JOHN T.,PRATT, JOHN K.,MOTTER, CHRISTOPHER E.,MARING, CLARENCE J.,LONGENECKER, KENTON L.,LIU, YAYA,LIU, DACHUN,KRUEGER, ALLA
申请号：
ES08831873
公开号：
ES2453591T3
申请日:
2008.09.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound or salt thereof, where: the compound corresponds in structure to formula I: ** Formula ** is selected from the group consisting of a carbon-carbon single bond and a carbon-carbon double bond； R1 is selected from the group consisting of hydrogen and methyl； R2 is selected from the group consisting of hydrogen, halo, hydroxy, methyl, cyclopropyl and cyclobutyl； R3 is selected from the group consisting of hydrogen, halo, oxo and methyl； R4 is selected from the group consisting of halo, alkyl, alkenyl, alkynyl, nitro, cyano, azido, alkyloxy, alkenyloxy, alkynyloxy, amino, aminocarbonyl, aminosulfonyl, alkylsulfonyl, carbocyclyl and heterocyclyl, where: (a) the amino, aminocarbonyl and aminosulfonyl are optionally substituted with: (1) one or two substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl and alkylsulfonyl, or (2) two substituents which, together with the amino nitrogen, form a single ring heterocyclyl, and (b) alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, alkynyloxy and alkylsulfonyl are optionally substituted with one or more substituents independently selected from the group consisting of halo, oxo, nitro, cyano, azido, hydroxy, amino, alkyloxy, trimethylsilyl , carbocyclyl and heterocyclyl, where: the amino is optionally substituted with: (1) one or two independently selected substituents ionized between the group consisting of alkyl, alkenyl, alkynyl, alkylcarbonyl, alkylsulfonyl, alkyloxycarbonyl, carbocyclyl, heterocyclyl, carbocyclylalkyl and heterocyclylalkyl, or (2) two substituents which, together with amino nitrogen, form a single ring heterocyclyl, and ( c) the carbocyclyl and the heterocyclyl are optionally substituted with up to three substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, halo, oxo, nitro, cyano, azido, hydroxy, amino, alkyloxy, trimethylsilyl, carbocyclyl and heterocyclyl, where : the amino is optionally substituted with: (1) one or two substituen
