An image pickup system includes a light source apparatus, an objective optical system, an image pickup device, a judging portion configured to judge: an object is observed in which of a distant view and a near view, and an image pickup control portion configured to set a reading mode of the image pickup device according to a judgment result of the judging portion. The light source apparatus is capable of sequentially emitting red light, green light and blue light. The image pickup control portion sets a single pixel reading mode when that the object is observed in the distant view is judged, and blue light is emitted from the light source apparatus, and sets to a pixel addition reading mode when that the object is observed in the distant view is judged, and red light is emitted from the optical apparatus.