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QUINOLINE OR QUINAZOLINE DERIVATIVE USED AS AXL INHIBITOR
专利权人:
ONO FARMASYUTIKAL KO.; LTD.
发明人:
INUKAI Takayuki,ИНУКАИ Такаюки,TAKEUTI Dzun,ТАКЕУТИ Дзун,YASUKHIRO Tomoko,ЯСУХИРО Томоко
申请号:
RU2016102036
公开号:
RU2666895C2
申请日:
2014.07.23
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely a novel heterocyclic compound of formula (I) or a salt thereof, where Ris (1) a C1-6 alkyl group optionally substituted with 1-2 R, (2) a C3-6 carbon ring selected from phenyl, cyclopropyl, cyclobutyl and cyclohexyl optionally substituted with 1-2 Ror (3) a 4 to 6 membered heterocycle selected from oxetane, tetrahydropyran, pyrazole and pyridine optionally substituted with 1 R, Ris (1) C1-4 alkyl group, (4) oxo group, (5) -ORgroup or (6) =NRgroup, Ris (1) C1-4 alkyl group, (2) a halogen atom, Ris (1) C1-4 an alkoxy group, (2) C1-4 haloalkyl group, (3) -ORgroup, Ris (1) hydrogen atom, (2) C1-4 alkyl group, Ris (1) -ORgroup, (2) SORgroup, (3) NRRgroup or (4) C3-6 carbon group selected from phenyl, cyclopropyl, cyclohexyl optionally substituted with 1 halogen atom, Ris (1) C1-4 alkyl group, optionally substituted by hydroxyl group or (2) a halogen atom, Ris (1) C1-4 alkyl group, optionally substituted by hydroxyl group, Ris hydrogen atom, Ris (1) by hydroxyl group or (2) C1-4 an alkoxy group, Ris (1) hydrogen atom (2) C1-5 alkyl group, substituted with 1 to 2 substituents selected from (a) 5-6 membered cyclic group selected from pyrrolidine, piperidine, piperazine, morpholine, dioxolane and phenyl, optionally substituted with 1 to 2 substituents selected from (i) a C1-4 alkyl group and (iii) halogen atom, (b) NRR, (c) hydroxyl group and (d) SORgroup Rand Rare (1) a hydrogen atom or (2) C1-4 alkyl group, R, R, R, Rand R- each, independently, represents (2) C1-4 alkyl group, A is (1) CH or (2) a nitrogen atom, L is (1) -O-, (2) -NH-, (3) -C(O)-, ring1 is 6-membered cyclic group selected from phenyl and pyridine,is a single bond, m = 0-4, n, p and q = 0-2, if m is two or more, the radicals Rmay be the same or different, and if two Rare a C1-3 alkyl group and are on the same carbon atom, Rtogether with the carbon atom to which they are attached, can form a C3-4 cycloalkyl ring, if n is
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