BONGARTZ, JEAN-PIERRE ANDRÉ MARC,LINDERS, JOANNES THEODORUS MARIA,MEERPOEL, LIEVEN,VAN LOMMEN, GUY ROSALIA EUGEEN,COESEMANS, ERWIN,BRAEKEN, MIRIELLE,BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR,BERWAER, MO
申请号：
ES08760584
公开号：
ES2522617T3
申请日:
2008.06.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula ** Formula ** including any stereochemically isomeric form thereof, in which A represents CH or N； the dotted line represents an optional bond in the case where A represents a carbon atom； X represents -O-C (>； = O) -； -C (>； = O) -C (>； = O) -； -NRxC (>； = O) -； -Z-C (>； = O) -； -Z-NRx-C (>； = O) -； -C (>； = O) -Z-； -NRx-C (>； = O) -Z-； -C (>； = S) -； -NRx-C (>； = S) -； -Z-C (>； = S) -； -Z-NRx-C (>； = S) -； -C (>； = S) -Z-； -NRx-C (>； = S) -Z-； Z represents a bivalent radical selected from C 1-6 alkanediyl, C 2-6 alkenodiyl or C 2-6 alkynediyl； wherein each of said C1-6 alkanediyl, C2-6 alkenodiyl or C2-6 alkynediyl may be optionally substituted with hydroxyl or amino； and wherein two hydrogen atoms bonded to the same carbon atom in C1-6 alkanediyl may optionally be replaced by C1-6 alkanediyl； Rx represents hydrogen or C1-4 alkyl； Y represents -C (>； = O) -NRx- or -NRxC (>； = O) -； R1 represents adamantanil； C3-6 cycloalkyl； aryl1 or Het1； R2 represents C3-6 cycloalkyl, phenyl, naphthalenyl, 2,3-dihydro-1,4-benzodioxynyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C3-6 cycloalkyl, phenyl, naphthalenyl, 2,3-dihydro-1,4-benzodioxynyl, 1,3-benzodioxolyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms may be optionally substituted with at least one substituent, in particular one, two, three, four or five substituents, each substituent being independently selected from hydroxyl； carboxyl； halo； C1-6 alkyl optionally substituted with hydroxyl； C1-6 polyhaloalkyl； C1-6 alkyloxy optionally substituted with C1-4 alkyloxy； C1-6 alkylthio； C1-6 polyhaloalkyloxy； C1-6 alkyloxycarbonyl in which C1-6 alkyl may be optionally substituted with aryl； cyano； C1-6 alkylcarbonyl； nitro； Not me； mono or di (C1-4 alkyl) amino； C 1-4 alkylcarbonylamino； -S (>； = O) p-C1-4 alkyl； R4R3N-C (>； = O) -； R4R3N-C1-6 alkyl； C3-6 cycloalkyl； C3-6 cycl
