Refers to compounds of the formula and M - L - X - - - X - l m and - - Where a is a Ring or Heterocyclic Aromatic or non Aromatic carbociclico as piperazine diketopiperazineAmong others, L and L are each alquileno (C1 - C6) X and x are each EsterAmides, ketones M and M are absent or are a Link and are each a rest containing cationic groups such as - NH - C (NH2) = NH, NH2, among others.Preferred compounds are: (3 - (4 - [3 - (2 - amino - 5 - guanidine - pentanoilamino) - propyl] piperazin-1-yl) - propyl) - amide acid - 2 - amino - 5 - guanidine acid {5 - [(2 - amino - 5 - guanidine pentanoilamino) methyl- piperazin] - 2 - Methyl amide acid} - 2 - amino - 5 - guanidine acid among others. It also relates to a Pharmaceutical composition.These compounds are partially or completely reverse the anticoagulant effects of coagulation inhibitors such as unfractionated heparin, low molecular weight heparin, among othersSE REFIERE A COMPUESTOS DE FORMULA Y-M-X-L-A-L-X-M-Y DONDE A ES UN ANILLO CARBOCICLICO O HETEROCICLICO AROMATICO O NO AROMATICO TAL COMO PIPERAZINA, DICETOPIPERAZINA, ENTRE OTROS L Y L SON CADA UNO ALQUILENO(C1-C6) X Y X SON CADA UNO ESTERES, AMIDAS O CETONAS M Y M ESTAN AUSENTES O SON UN ENLACE Y E Y SON CADA UNO UN RESTO QUE CONTIENE GRUPOS CATIONICOS TALES COMO -NH-C(NH2)=NH, NH2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3-{4-[3-(2-AMINO-5-GUANIDINO-PENTANOILAMINO)-PROPIL]-PIPERAZIN-1-IL}-PROPIL)-AMIDA DEL ACIDO 2-AMINO-5-GUANIDINO-PENTANOICO {5-[(2-AMINO-5-GUANIDINO-PENTANOILAMINO)-METIL]-PIPERAZIN-2-ILMETIL}-AMIDA DEL ACIDO 2-AMINO-5-GUANIDINO-PENTANOICO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS REVIERTEN PARCIAL O COMPLETAMENTE LOS EFECTOS ANTICOAGULANTES DE INHIBIDORES DE LA COAGULACION TALES COMO HEPARINA NO FRACCIONADA, HEPARINA DE BAJO PESO MOLECULAR, ENTRE OTROS
