The invention disclosed relates to a water-soluble composition having enhanced bioavailability useful for the treatment of depression which comprises a synergistic combination of curcumin, at least an antioxidant, a hydrophilic carrier and a fat. The invention also discloses a process for the preparation of the curcumin composition which comprises the steps of dissolving curcumin, at least one antioxidant, a hydrophilic carrier and a fat in a solvent to form a homogenous mass warming the resultant mass at a temperature ranging from 25°C to 60°C for a period of 4 to 8 hours to obtain a dry wet mass removing the solvent by evaporation to form dry mass and pulverizing the dry mass to form a fine powder.
