FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "TSENTRALNYJ NAUCHNO-ISSLEDOVATELSKIJ INSTITUT TRAVMATOLOGII I ORTOPEDII IMENI N.N. PRIOROVA" MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJSKOJ FEDERATSII (
发明人:
MIRONOV SERGEJ PAVLOVICH,Миронов Сергей Павлович,KOLESOV SERGEJ VASILEVICH,Колесов Сергей Васильевич,NIKITIN SERGEJ SERGEEVICH,Никитин Сергей Сергеевич,GUBIN SERGEJ PAVLOVICH,Губин Сергей Павлович,SAZ
申请号：
RU2014123742
公开号：
RU2557890C1
申请日:
2014.06.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine.SUBSTANCE: biocompatible implant (BI) made of magnetic material in a biocompatible matrix (BM) is placed loosely along a posterior surface of an injured spinal cord of an experimental animal (EA) The EA is immersed periodically into a constant magnetic field. Its magnetic vector is aligned with a craniocaudal direction of spinal tracts. The BM of the BI is animal or herbal gelatine, wherein ferromagnetic magnetite or ferromagnetic ferrite nanoparticles 18-42 wt % with a particle size of 2.0-38 nm and at a magnetic field intensity (N) of 5-10 mT are immobilised as a magnetic material of the BI. The magnetic exposure covering the traumatic spinal injuries involves the combined effect of the magnetic field of the BI and the external rotating magnetic field at a magnetic induction of 0.15-0.35 T. The external magnetic exposure frequency is 1 or 2 times a day the length is from 2 to 8 minutes per one session the number of sessions is from 2 to 4. Animal gelatine in the BM of the BI can represent agar-agar, whereas herbal gelatine is pectin. The BM of the BI can additionally contain polyamines contributing to cell growth and proliferation, e.g. spermine or spemidine, in an amount of 1-5 wt %.EFFECT: method enables recovering the spinal cord function sufficiently completely in the distal direction from the injury region, providing the favourable conditions for the adequate neuroglial growth with recipients long neuron penetration from the intact proximal portion of the spinal cord into the distal one to ensure its conductive function, reducing the cicatrisation within the spinal injury, and eliminating the cerebral tissue oedema.3 cl, 8 exИзобретение относится к экспериментальной медицине, травматологии и ортопедии, хирургическому лечению травматических повреждений спинного мозга с одновременным ускорением его регенерации. По задней поверхности травмированного спинного мозга экспериментального животного (ЭЖ) без его компрессии размещают биосовместимый импла
