A game-based platform for exercise procedures for prevention of venous thromboembolism (VTE) may have a wearable sensor and human-machine interface technology configured to monitor and encourage VTE prevention exercises. The wearable sensor may attach to a patient's foot to monitor movement of the ankle joint, such as pronation, supination, dorsiflexion, or plantar flexion. The patient may be instructed to move their foot by operating their ankle to move a cursor around on a screen to reach a target. Targets may be randomly presented to keep the patient moving their foot for a specified duration of time.