There are provided a biological sensor control device, an operation method and operation program thereof, and a biological sensor system capable of effectively using the power of a battery of a wearable biological sensor device within a measurement period. In a case where the measurement period of a wearable biological sensor device is shortened, a determination unit changes the driving conditions so as to increase the driving power of the wearable biological sensor device by increasing the number of measurement items and/or by shortening the measurement interval. The determination unit determines the driving conditions in which the remaining capacity becomes a preset value or less at the end of the measurement period.