AMERICAN HOME PRODUCTS CORPORATION;RESEARCH FOUNDATION FOR MEDICAL HYGIENE;PETANESCA, SUZANA;GANDY, SAM;FRAIL, DONALD, E.
发明人:
PETANESCA, SUZANA,GANDY, SAM,FRAIL, DONALD, E.
申请号：
WO2000US30310
公开号：
WO0135106(A2)
申请日:
2000.11.03
申请国别(地区):
世界知识产权组织国际局
年份:
2001
代理人:
摘要：
The present invention relates to identification of agents that play a role in regulating brain amyloid- beta (A beta ) levels <i>in vivo</i>. The invention provides compounds and methods of using such compounds to treat amyloidogenic conditions. It also provides a useful animal model for screening for and evaluating candidate amyloid inhibiting or therapeutic compounds. In particular, ovariectomy (ovx) and estrogen replacement were found to affect brain A beta levels in guinea pigs. Long-term ovx of guinea pigs resulted in increased levels of total brain A beta , as compared to intact animals, and the A beta 42/A beta 40 ratio was also elevated. Treatment of ovx guinea pigs with beta 17-estradiol for ten days partially reversed the ovx-associated increase in brain A beta levels.
