JAMES KOWALSKI,JAY PARTHIBAN LAKSHMAN,ABU T. M. SERAJUDDIN,YATINDRA JOSHI
申请号：
MYPI 20062526
公开号：
MY152185A
申请日:
2006.06.01
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE SUBJECT INVENTION PROVIDES A PHARMACEUTICAL TABLET FORMULATION COMPRISING PER TABLET THE FOLLOWING INGREDIENTS: (A) A COMPOUND AS AN ACTIVE INGREDIENT, WHEREIN THE COMPOUND HAS A FORMULA: WHEREIN R IS SUBSTITUTED ADAMANTYL AND N IS AN INTEGER FROM 0 TO 3 OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； (B) A HYDROXYPROPYL METHYLCELLULOSE WITH AN APPARENT VISCOSITY OF 80,000 CP TO 120,000 CP (NOMINAL VALUE 100,000 CP) WHEN PRESENT IN A 2% SOLUTION: (C) A MICROCRYSTALLINE CELLULOSE； AND (D) A MAGNESIUM STEARATE THE SUBJECT INVENTION ALSO PROVIDES A PHARMACEUTICAL TABLET FORMULATION, COMPRISING PER 400 MG TABLET THE FOLLOWING INGREDIENTS: (A) 1-[(3—HYDROXY-ADAMANT-1-YLAMINO)—ACETYL]-PYRROLIDINE—2 (S) —CARBONITRILE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； (B) A HYDROXYPROPYL METHYLCELLULOSE IN AN AMOUNT OF ABOUT 160 MG, WHEREIN THE HYDROXYPROPYL METHYLCELLULOSE HAS AN APPARENT VISCOSITY OF 80,000 CP TO 120,000 CP (NOMINAL VALUE 100,000 CP) WHEN PRESENT IN A 2% SOLUTION； (C) A MICROCRYSTALLINE CELLULOSE IN AN AMOUNT OF 120 MG； (D) A LACTOSE IN AN AMOUNT OF ABOUT 16 MG； AND (E) A MAGNESIUM STEARATE IN AN AMOUNT OF 4 MG. THE SUBJECT INVENTION ALSO PROVIDES A PHARMACEUTICAL TABLET FORMULATION COMPRISING PER TABLET THE FOLLOWING INGREDIENTS: (C) A COMPOUND AS AN ACTIVE INGREDIENT, WHEREIN THE COMPOUND HAS A FORMULA: WHEREIN R IS SUBSTITUTED ADAMANTYL AND N IS AN INTEGER FROM 0 TO 3； OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； AND (D) A HYDROXYPROPY) METHYLCELLULOSE WITH AN APPARENT VISCOSITY OF 80,000 CP TO 120,000 CP (NOMINAL VALUE 100,000 CP) WHEN PRESENT IN A 2% SOLUTION.
