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Improve the tune release formulation of 1- [((3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2 (multiple) of release
专利权人:
Novartis AG
发明人:
Joshi, Yatindra,Lakshman, Jay Parthiban,Serajuddin, Abu T M,Kowalski, James
申请号:
NO20080177
公开号:
NO343043B1
申请日:
2008.01.10
申请国别(地区):
NO
年份:
2018
代理人:
摘要:
The present invention provides a kind of tablet, every slice prescription includes the compound of following components as active constituent, and wherein compound has following formula, and it is an integer from 0 to 3 that wherein R, which is the firm n replaced, or its pharmaceutically acceptable salt, hydroxypropyl methyl cellulose have apparent viscodity 80.000 centipoise is to 120.000cp (centipoise) rated value 100.000; it is invented when the theme for being present in 1% microcrystalline cellulose and magnesium stearate The Feasibility Study for Intensification and Extension of Tseung Kwan O New Town solution A and additionally provides a kind of tablet formulations; including every 400 tablet following component 1- [3-hydroxy adamant-1-ylamino) acetyl group] pyrrolidine-diones (multiple) nitrile; or its pharmaceutically acceptable salt; the amount of hydroxypropyl methyl cellulose is about 160 milligrams, and it is 80. that wherein hydroxypropyl methyl cellulose, which has apparent viscosity,000 centipoise 120.000 centipoise is to 100.000 centipoise (rated value), it is 1% 120 milligrams of lactose and about 16 milligrams when being present in solution A microcrystalline cellulose dosage, a kind of tablet is additionally provided with a kind of 4 milligrams of The Feasibility Study for Intensification and Extension of Tseung Kwan O New Town theme inventions of magnesium stearate, every slice prescription includes the compound of following components as active constituent, wherein compound has following formula, wherein r is the hard of substitution, and n be 0 to 3 integer or its pharmaceutically acceptable salt and hydroxypropyl methyl cellulose and apparent viscosity 80.000 centipoise is to 120.000 centipoise 100.000 centipoise (rated value), when being present in 1% solution.Foreliggende oppfinnelse tilveiebringer en farmasøytisk tablettformulering som innbefatter per enhetsdoseringsform f. eks per tablett følgende ingredienser: (a) en forbindelse so
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