COMPOSITION PHARMACEUTIQUE COMPRENANT UN COMPRIME SPHEROIDAL A UNITES MULTIPLES CONTENANT DE L'ESOMEPRAZOLE ET UN SEL DE QUALITE PHARMACEUTIQUE DE CELUI-CI, ET PROCEDE DE PREPARATION DE LA COMPOSITION PHARMACEUTIQUE
CHO, HYUK JUN,KIM, MIN WOOK,IM, HO TAEK,KIM, YONG IL
申请号：
CA3071623
公开号：
CA3071623A1
申请日:
2018.09.28
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Provided are a pharmaceutical composition including a core in a form of amulti-unit spheroidal tablet (MUST) containingesomeprazole or a pharmaceutically acceptable salt thereof, wherein thepharmaceutical composition is dissolved by 50 percent(%) or more within 15 minutes of an in vitro dissolution test； and a method ofpreparing the pharmaceutical composition. According tothis, in case that the pharmaceutical composition is developed as the multi-unit spheroidal tablet, the dissolution may be accelerated in acondition of a slow stirring rate than that of a conventional pelletformulation or single tablet. Also, proton pump inhibitors (PPI)-baseddrugs including esomeprazole may be dissociated by gastric acid having a lowpH, consequently inducing a decrease in bioavailabilityof the drug, but the pharmaceutical composition according to this may beminimize this.
