IMUTHES LIMITED;Institute Of Organic Chemistry And Biochemistry Av CR, v.v.i.;Vyzkumny Ustav Veterinarniho lékarstvi, v.v.i.
发明人:
申请号：
EP13150255.1
公开号：
EP2578598A1
申请日:
2009.03.17
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The invention provides a compound of Formula IwhereinR1, R4 and R5 are each independently selected from hydrogen, acetyl, hydrocarbyl；R2 is a hydrocarbyl, a lipid moiety, a lipid acyl moiety； or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety；R8 is acetyl；X is a peptide chain；wherein hydrocarbyl is preferably acyl or alkyl,which can act as an adjuvant.The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen or DNA encoding the antigen, in vaccines, e.g., DNA vaccines.
