PETERSON SCOTT,PESTANO LINDA,KOPPENOL SANDY,HAUSMAN DIANA F.,KIRKMAN ROBERT L.,MILLARD JEFFREY
申请号：
ARP120100627
公开号：
AR085490A1
申请日:
2012.02.24
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
1. Formulation of lipococcal vaccine containing glucose, an adjuvant and an immune agent for immunotherapy and / or cancer treatment: 1: a lipococcal vaccine, characterized by: (a) a complex peptide including at least two recurrences Core: tsapdtrppgstpahgv (SEQ ID No.1) or at least 85% of the sequences are exactly the same as SEQ ID No.1, or are linearly exchanged； in these sequences, s and t can be replaced separately to set the upper limit of hydrate related to cancer；(b) A kind of polymer leaching solution in covalent a (a) formula: H2n - (Aa1) * (aa2) * (aa3) - Oh, in each case, Aa1 is selected from s, t, K, R or C respectively； aa2 is selected from s, t, K, R or C respectively； aa3 is selected from L or g respectively； In each case, it is a kind of polymer fat with covalent with the remaining amino acids； (c) a formula (1),At least one of R1, R2, R3, R5, R6 and R7 is a high fat group selected from the formula group residue (3),Where x, x1, X2, X3 are independent - co-o-ch2-Z is - nh-u-o； K, m, and R are independent between 0 and 30； N and Q are independent between 0 and 6； Y4 is a-- yes.Y-nh - at least one of y1r1, y2r2, y3r3, y5r5, y6r6 and y7r7 is a monovalent phosphate equivalent (MPE),where each equivalent of monovalent phosphate is, independently, [a] -RC (O) OH where R is a substituted or unsubstituted alkyl group of 1-4 carbons, or [b] is independently selected from the group that consists of -OB (OH) O, -OP (O) (OH) O, -OS (O) (O) (OH) O, and -OP (= O) (OH) -OP (= O) (OH ) Or, where R is hydrogen, or a substituted or unsubstituted alkyl group of 1-4 carbons, and if R is a substituted alkyl group, the substituents are -OH or -NH2, where R8 is selected from the group consisting of H, OH, OR9, a portion that in combination with Y8 forms an equivalent of monovalent phosphate as defined,As defined in formula group (3) of formula (I) - (VIII), R9 is a group of tar or acid salts with a length between 1 and 10 carbon, wherein the combination of glycerin is a o
