FRANK S. MENNITI,ROBERT A. VOLKMANN,DAVID R. ANDERSON
申请号：
ARP150103084
公开号：
AR103199A1
申请日:
2015.09.25
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt, solvate, hydrate, prodrug, taut u00f3mero or stereoisomer thereof, characterized in that: l u00b9 is c u2081 u208b u2085 linear or branched alkyl, optionally substituted with one or more substituents selected from G He is or u00b9 u2070 nh u2082 nhr u00b9 u2070 Oh,,,,And N (r u00b9 u2070) (United r u00b9 u2070) not more than one Oxygen or nitrogen to carbon； or, l u00b9 is selected from a group consisting of - C (o) -, - C (o) - c u2081 u208b u2083 alquilenilo -, - C (o) o - c u2081 u208b u2083 alquilenilo -, - (o) u2082 - S, - S (o) u2082nh -, - C (o) NH -, - C (o) - nr u00b9 u2070,And a Link； and r u00b9 u2070 r u00b9 u2070 are each independently selected from the group h； c u2081 u208b u2086 alkyls can be optionally substituted with one or more substituents selected from the group consisting c u2081 u208b u2085 or - Oh, alkyl, opo u2083 u207b u00b2m u2082, op (OR) (OH) u2082,OC (OC) alkyl and o-alkyl (OR) where M is a metal and monovalent cation； cycloalkyl can be optionally substituted by one or more substituents selected from alkyl or - Oh Group and c u2081 u208b u2085 while no more than one Oxygen Molecule is attached to a carbon or r u00b9 u2070 and R； u00b9 u2070 can form a Heterocycles with nitrogen which are United； r u00b9 is a cycloalkyl,Aryl or heteroaryl, which can be replaced optionally with one or more substituents selected from the group consisting alquilarilos Oh, CN, halogen, c u2081 u208b u2086, alquilarilos c u2081 u208b u2086 or - or - r u00b9 u2070, opo u2083 u207b u00b2m u2082, op (OR) (OH) u2082, sh, S - r u00b9 u2070, c u2081 u208b u2085 alkyl, branched alkyl, NH u2082 nhr u00b9 u2070 NHS (,, OR) u2082r u00b9 u2070, N (r u00b9 u2070) (nr u00b9 u2070), where M is a cation and nhcor u00b9 u2070 monovalent metal； X is selected from o, S, - S (o) -,And u2082 - S (o)； and are independently H or alkyl, halogen c u2081 u208b u2085； L u00b2 is a Link, u2099 - (ch u20
