4 - Deoxy Derivatives of 4 - (S) - amino avermectin has the formula (1) in which the position 4 \"has the configuration (S) in which R1 is alkyl and cycloalkyl - 12 C1, C2 or C3 - 8 alquenilo - 12 R2 is Hydrogen, alkyl C1 - 12 unsubstituted or substituted Penta mono - or alquenilo C2 - 12 n Or replaced or substituted Penta mono - alkyl - 12 R3 is C1, C1 - 12 mono - alkyl substituted penta -,C1 - 12 - alkoxy alkyl substituted C1 - 12 mono - or Penta substituted cycloalkyl substituted C3 - 12 mono - or Penta substituted or unsubstituted alquenilo C2 - 12 mono - substituted penta - 12 cicloalquenilo C4 unsubstituted or substituted Penta mono -,Alquinilo C2 - 12 not replaced or mono - or Penta substituted R2 and R3 together are a Bridge alquileno three to Seven members or alquenileno four to Seven members in each of which a CH2 Group may have been replaced by o, s or NR4 where the substituents of the radicale S alkyl, alkoxy alkyl, alquenilo, alquinilo, alquileno, alquenileno,Cycloalkyl and cicloalquenilo mentioned are selected from the group consisting of halogen, Oh, haloalquilo c1-2, CN, SCN, NO2 (rent, IF C1 - C2 alquinilo 12) 3, - 6, - 8 cycloalkyl C3 is replaced or not replaced with from one to three Methyl groups, norbornilenilo, cicloalquenil C3 - 8 or is replaced or not replaced with from one to three Methyl groups halocicloalquilo C3 - 812 - alkoxy C1, C1 - alkoxy 6-alkoxy C1 - C3 - cicloalcoxi 6, 8, 12 Alquiltio haloalcoxi C1, C1 - C3 - cicloalquiltio 12, 8, 12 alquilsulfinilo haloalquiltio C1, C1 - C3 - cicloalquilsulfinilo 12, 8, 12 halocicloalquilsulfinilo haloalquilsulfinilo C1 - C3 -, 8 -, 12 alquilsulfonilo C1 cicloalquilsulfonilo C3, - 8, haloalq Uilsulfonilo C1 - C3 - halocicloalquilsulfonilo 12, 8, 8 alquinilo alquenilo C2, C2 8, NH2,NH (alkyl C1 - 6), NH (hidroxialquilo C1 - 6, N - (alkyl) - 6 (C1) hidroxialquilo C1 - 6), N (phenyl) (hidroxialquilo C1 - 6), N (C1 2 - alkyl, - C (6) = x) ZR5, - or - C (R6 = x), or - C (= x) n (R6, R8) - NHC (= x) R6
