This also relates to compositions comprising at least one composed of biphenylene replaced, and Methods of using the compounds to Treat or prevent biphenylene replaced an hcv infection in a patient.Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt thereof in which Y1 is - C (R5) - 2, - 2 - CH2C (R5), OC (R5) - 2 or - 2 - (R3)； y2 is - C (R5) 2 - 2 - CH2C (R5), OC (R5) - 2 or - 2 - (R3)； each occurrence of R1 is selected regardless of C1 - 6 h, alkyl, moped Oalquilo 3 to 6 members, Halo, haloalquilo C1 - CN, - 6, - Oh, - O - (C1 - alkyl - or - (6) and haloalquilo C1 - 6)Or two groups R1 which are united in the same Ring optionally can be joined to form a Group - M - (CH2), in which the Group - M - (CH2) may optionally have one or two of their remains - CH2 - replaced independently by a n or o Atom, so that when two Atoms n u or est So present,Are not adjacent to each other； each occurrence of R2 are independently selected from H and alkyl, Halo C1 - 6； each occurrence of R3 are independently selected from alkyl F, C1 and C1 - alkyl - or 6 - 6, or two groups R3 that are attached to the same Atom If can join together to form a Gru Po - (CH2) n -； R4 represents 1 to 3 Optional Ring substituents.That may be the same or different and are selected from C1 - 6 alkyl, Halo and haloalquilo C1 - 6； each occurrence of R5 is selected regardless of C1 - 6 h, alkyl, cycloalkyl of 3 to 6 members, Halo, haloalquilo C1 - CN, - 6, - Oh, - or - (alkyl C1 - (6) and or haloalquilo C1 - 6)R5 or two groups that are attached to the same carbon Atom optionally can be joined to form a Group - (CH2) n -, in which the Group - N - (CH2) may optionally have one or two of their remains - CH2 - replaced independently by a n or o Atom, so that when two Atoms N or o are present,Can not be adjacent to each other； each occurrence of Ra is selected regardless of C1 - 6 h, alkyl, cycloalkyl, phenyl 3 to 6 members and heterocicloalquilo 3 to 6 members, where the Group heterocicl
