BACK JAAP WILLEM,BOSHUIZEN RONALD,PUIJK WOUTER CORNELIS,TURKSTRA JOHAN
申请号：
IN201817004031
公开号：
IN201817004031A
申请日:
2018.02.02
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present disclosure provides humanized anti human CCR7 antibodies and compositions comprising such antibodies. The antibodies and compositions are useful in the treatment of a cancer of which the tumour cells express a CCR7 receptor in the treatment of inflammatory conditions conditions or complications arising from tissue or organ transplantations and conditions or complications arising from or associated with fibrosis. Experimental results are detailed for a few antibodies derived from mouse antibodies. The mouse antibody with the internal name mab729 having as CDRs VH1:GLTFRDFA VH2:ISSGGFYT VH3:VRRAYRYDGTGDYSALDY VLl:QDIGPS VL2:ATS VL3:LQFASSPLT is further humanized (internal name mAB 650_H 1L1). Said antibody inhibits CCR7 receptor internalization as shown by experimental results.
