WANG, LI-HSIEN,DORE, ANTHONY T.,STEVENS, SEAN,MURPHY, ANDREW J.,WANG, Li-hsien,DORE, Anthony T.,STEVENS, Sean,MURPHY, Andrew J.
申请号：
RSP20140677
公开号：
RS53683B1
申请日:
2012.10.29
申请国别(地区):
RS
年份:
2015
代理人:
摘要：
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R± locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Genetski modifikovan miš, naznačen time što uključuje zamenu na endogenom mišjem IL-6 lokusu mišjeg gena koji kodira IL-6 s humanim genom koji kodira humani L-6, pri čemu je humani gen koji koji kodira humani IL-6 pod kontrolom endogenih mišjih regulatornih elemenata na endogenom mišjem IL-6 lokusu.Prijava sadrži još 16 patentnih zahteva.
