3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use

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专利权人:

ITEOS THERAPEUTICS

发明人:

Stefano Crosignani,Sandra Cauwenberghs,Gregory Driessens,Frederik Deroose

申请号：

US14619589

公开号：

US09758505B2

申请日:

2015.02.11

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention relates to compound of Formula Ior pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.

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