您的位置: 首页 > 农业专利 > 详情页

Bicyclo Acid GPR120 Modulators [2.2.2]
专利权人:
Bristol-Myers Squibb Company
发明人:
SHI, Yan,ZHANG, Hao,CHENG, Peter T.W.,TAO, Shiwei
申请号:
ES14721602
公开号:
ES2765973T3
申请日:
2014.03.13
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A compound of formula (I): ** (See formula) ** or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, in which: L1 is independently L4-O or O-L4; L2 is independently a 0-2 Rc substituted hydrocarbon linker or a 0-2 Rc substituted hydrocarbon heteroatom linker; wherein said hydrocarbon linker has one to six carbon atoms and can be linear or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and a group selected from O, -CO-, S, -SO-, -SO2-, NH and N (C1-4 alkyl); L4 is independently a hydrocarbon bond or linker; wherein said hydrocarbon linker has one to four carbon atoms and can be linear or branched; R1 is independently selected from: C6-10 carbocycle and a 5 to 10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S (O) p; wherein said carbocycle and heterocycle are substituted with 0-4 R3 and 0-1 R4; R2 is independently selected from: CO2H and -CONHSO2 (C1-4 alkyl); R3, at each occurrence, is independently selected from: halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 haloalkylthio, and NO2; R4 is independently -L3-R5; L3 is independently selected from: a bond, O, and C (= O); R5 is independently selected from: phenyl and a 5-6 membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NRb, O, and S (O) p; wherein each residue on the ring is substituted with 0-2 Ra; Ra, at each occurrence, is independently selected from: halogen, C1-4 alkyl, C1-4 alkoxy and C1-4 haloalkyl; Rb, at each occurrence, is independently selected from: H, C1-4 alkyl, and - (CH2) 0-2- (phenyl substituted with 0-3 Rd); Rc, at each occurrence, is independently selected from: halogen, OH, C1-4 alkyl, C1-4 haloalkyl, and C1-4 alkoxy; Rd, at each occurrence, is independently selected from: halogen, C1-4 alkyl, C1-4 alkoxy and C1-4 haloalkyl; and p, independently in each case, is selected from 0, 1 and 2.Un compuesto
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充