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СПОСОБ ЛЕЧЕНИЯ АТЕРОСКЛЕРОЗА У СУБЪЕКТОВ С ВЫСОКИМ УРОВНЕМ ТРИГЛИЦЕРИДОВ
专利权人:
НОВАРТИС АГ (CH)
发明人:
АРАИ Йосие (JP),БРУССО Маргарет Элизабет (US),ГУ Джесси (US),ХАЯСИ Томоко (JP),МИТАНИ Хиронобу (JP),МОГИ Мунето (US),НОНОМУРА Кадзухико (JP),ЯМАДА Кен (US)
申请号:
RU2014104377/15
公开号:
RU2014104377A
申请日:
2012.07.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for treating, preventing or reducing atherosclerosis or dyslipidemia intensity, or a method of increasing HDL-C and / or reducing LDL-C, in a subject with high triglyceride levels comprising administering a therapeutically effective amount of a compound of the following formula I: or a pharmaceutically acceptable salt thereof where: C is a core structure selected from: Y and Z are independently CH or N a and ring B independently are phenyl or 5- or 6-membered heteroaryl, wherein phenyl and heteroaryl are optionally substituted with 1-3 substituents independently selected from Ci ^ alkyl, alkoxy, halogen, halogen-Ci ^ alkyl, halo, alkoxy, amino, alkylamino, di-alkylamino, and Ctsikloalkila Ctsikloalkoksi D Ctsikloalkilom is phenyl, a 5- or 6-membered heteroaryl, wherein phenyl and heteroaryl are optionally substituted with 1-3 substituents independently selected from 1-3 substituents independently selected from Ci ^ alkyl, alkoxy, CN, NO, Ctsikloalkil-Ci ^ alkyl, halo, halo-Ci ^ alkyl, halo, alkoxy, amino, alkylamino, di-alkylamino, and Ctsikloalkila Ctsikloalkoksi L is a linker selected from Ci ^ alkyl (straight or branched), or a linker selected from: with the proviso that the central structure of the C and L do not form a NN bond or nO bond Xotsutstvuet or is the CR, where Robrazuet with Rsleduyuschee ring: Ryavlyaetsya C (O) O alkyl, C (O) alkyl or 5- or 6-membered heteroaryl, optionally substituted with 1-3 substituents independently selected from Ci ^ alkyl, Ci ^ alkyl, hydroxy, alkoxy, optionally substituted alkoxy, hydroxy, halogen or -S (O) Ci ^ alkyl amino, alkylamino, di-alkylamino, amino-Ci ^ alkyl, Ci ^ alkyl-alkylamino, di-alkylamino-Ci ^ alkyl (gidroksiSalk
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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