CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人:
JEUN, SIN SOOKR,전신수,KIM, SEONG MUKKR,김성묵
申请号：
KR1020140054764
公开号：
KR1020150128043A
申请日:
2014.05.08
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to an anti-cancer use by combining stem cells which secretes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TMZ and, more specifically, to a function which enhances TRAIL-mediated cell killing activity by sensitizing glioma cells through a molecular mechanism such as up-regulation of DR5 expression, ERK activation, apoptosis inhibitory protein down-regulation, caspase activation.COPYRIGHT KIPO 2016본 발명은 TRAIL(Tumor necrosis factor-related apoptosis-inducing ligand)을 분비하는 줄기세포 및 TMZ의 조합에 따른 항암 용도에 관한 것으로, 보다 구체적으로는, 이들의 조합에 따른, DR5 발현의 상향조절, ERK 활성화, 세포사멸 억제 단백질 하향조절, 카스파아제 활성화 등의 분자적 메커니즘에 의해 신경교종 세포를 민감화(sensitizing)시킴으로써 TRAIL-매개된 세포사멸능을 강화시키는 기능에 관한 것이다.
