CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人:
JEUN, SIN SOOKR,전신수,KIM, SEONG MUKKR,김성묵
申请号：
KR1020130087594
公开号：
KR1020150012136A
申请日:
2013.07.24
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to an anticancer use of combination of stem cells secreting TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand) and MK886, and more specifically, to a function of reinforcing trail-intermediated cell killing activity by sensitizing neuroglioma cells by molecular mechanism such as CHOP inducement, upregulation of DR5 expression, downregulation of surviving, activation of caspase, activation of p38 MAPK, etc according to combination thereof.COPYRIGHT KIPO 2015본 발명은 하는 TRAIL(Tumor necrosis factor-related apoptosis-inducing ligand)를 분비하는 줄기세포 및 MK886의 조합에 따른 항암 용도에 관한 것으로, 보다 구체적으로는, 이들의 조합에 따른 CHOP 유도, DR5 발현의 상향조절, 서바이빈 하향조절, 카스파아제 활성화, p38 MAPK 활성화 등의 분자적 메커니즘에 의해 신경교종 세포를 민감화(sensitizing)시킴으로써 TRAIL-매개된 세포사멸능을 강화시키는 기능에 관한 것이다.
