Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis

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专利权人:

发明人:

申请号：

EP07075019.5

公开号：

EP1849480A3

申请日:

2004.06.23

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

Methods and compositions for restoring sensitivity to the antitumorigenic effects of antiestrogen therapy and/or cytotoxic therapy and inducing cell apoptosis are provided. Contacting tumor cells to GP88 antagonists (e.g., anti-GP88 antibodies, anti-GP88 antisense nucleic acids, GP88 siRNA, and small molecules) induces apoptosis and restores sensitivity to the antitumorigenic effects of antiestrogen therapy and cytotoxic therapy.

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中国工程科技知识中心

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