ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.;NATIONAL UNIVERSITY OF SINGAPORE
发明人:
Dario Campana,Yu-Hsiang Chang
申请号：
US15857268
公开号：
US20180135015A1
申请日:
2017.12.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompasses methods for use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases.
