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複合造粒物及び速放性錠剤並びにこれらの製造方法
专利权人:
信越化学工業株式会社
发明人:
平間 康之,丸山 直亮
申请号:
JP2014231521
公开号:
JP6307417B2
申请日:
2014.11.14
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
Provided is a rapid release tablet excellent in binding capability and disintegrability and also excellent in storage stability and the like. More specifically, provided are a granulated composite comprising low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight and D-mannitol, wherein the D-mannitol contains 0.9% by weight or less of D-sorbitol a rapid release tablet comprising the granulated composite and a drug and a method for producing a granulated composite comprising the steps of: mixing low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight, first D-mannitol, and water to obtain an aqueous dispersion, and granulating while adding the aqueous dispersion to second D-mannitol, wherein the first D-mannitol and the second D-mannitol contain 0.9% by weight or less of D-sorbitol in total.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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