KRUCZYNSKI, Anna,CREANCIER, Laurent,KALOUN, El Bachir,BEDJEGUELAL, Karim,RABOT, Rémi
申请号：
ES13741791
公开号：
ES2634314T3
申请日:
2013.07.29
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of the following general formula (I): ** Formula ** or pharmaceutically acceptable salt or solvate thereof, tautomer thereof, or stereoisomer or mixture of stereoisomers thereof in any proportion, such as a mixture of enantiomers, particularly a mixture racemic, in which: - Y1 and Y4 each represent, independently of each other, a CH group or a nitrogen atom, with the proviso that at least one of Y1 and Y4 represents a nitrogen atom, - Y2 represents a CX-Ar group, - Y3 represents a CW group, - Ar represents an aryl or heteroaryl group optionally substituted with one or more groups selected from a halogen atom, (C1-C6) alkyl, haloalkyl (C1-C6), haloalkoxy (C1-C6), halothioalkoxy (C1-C6), CN, NO2, OR11, SR12, NR13R14, CO2R15, CONR16R17, SO2R18, SO2NR19R20, COR21, NR22COR23, NR24SO2R25, and R26NR27R28 and / or optionally condensed to a heterocycle, - represents a divalent group selected from O, S, S (O), S (O) 2, NR4, S (NR4), S (O) (NR4), 25 S (O) 2 (NR4), NR4S, NR4S (O), NR4S (O) 2 , CH2, CH2S, CH2S (O), CH2S (O) 2, SCH2, S (O) CH2, S (O) 2CH2, CH2CH2, CH>； = CH, C≡C, CH2O, OCH2, NR4CH2, and CH2NR4, - W represents a group R5, SR5, OR5 or NR5R6, - U represents a group CH2 or NH, one or more hydrogen atoms that can be substituted by a (C1-C6) alkyl group, - V represents C (O), C (S) or CH2, - n represents 0 or 1, - R1 represents a hydrogen atom, or an OR7 or NR7R8 group, - R2 represents a hydrogen atom, an optionally substituted heterocycle, NO2, OR9 or NR9R10, - R3 , R4, R11 to R25 and R27 to R28 each represent, independently from each other, a hydrogen atom or a (C1-C6) alkyl group, - R5 and R6 each represent, independently from each other, a hydrogen atom or a (C1-C6) alkyl, an optionally substituted aryl group or optionally substituted benzyl, - R7, R8, R9 and R10 each independently represent each other a hydrogen atom or a (C1-C6) alkyl or optionally substituted (C3-C12) cycloalkyl or an optionally substituted heterocycle group, and - R26 represents a (C
