KALOUN, El Bachir,BEDJEGUELAL, Karim,RABOT, Rémi,KRUCZYNSKI, Anna,SCHMITT, Philippe,PEREZ, Michel,RAHIER, Nicolas
申请号：
ES12701884
公开号：
ES2661695T3
申请日:
2012.01.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compound of the following general formula (I): ** (See formula) ** or pharmaceutically acceptable salt or solvate thereof, tautomer thereof, or stereoisomer or mixture of stereoisomers thereof in any proportion, such as a mixture of enantiomers, particularly a racemic mixture, in which: - Y1 and Y4 each independently represent each other, a CH group or a nitrogen atom, - Y2 represents a CX-Ar group and Y3 represents a nitrogen atom or a CW group, or Y2 represents a nitrogen atom or a group CH and Y3 represents a CX-Ar group, with the proviso that: ♦ at least one already two groups Y1, Y2, Y3, and Y4 represent a nitrogen atom, and ♦ Y2 and Y4 cannot represent a nitrogen atom at the same time, - Ar represents an aryl or heteroaryl group optionally substituted by one or more groups selected from a halogen atom, (C1-C6) alkyl, (C1-C6 ) haloalkyl, (C1-C6) haloalkoxy, (C1-C6) halotium alkoxy, CN, NO2, OR11, SR12, NR13R14, CO2R15, CONR16R17, SO2R18, SO2NR19R20, COR21, NR22COR23, NR24SO2R25 and R26NR27R28 and / or optionally fused to a heterocycle, - X represents a divalent group selected from O, S, S (O), S (O) 2, NR4, S (NR4), S (O) (NR4), S (O) 2 (NR4), NR4S, NR4S (O), NR4S (O) 2, CH2, CH2S , CH2S (O), CH2S (O) 2, SCH2, S (O) CH2, S (O) 2CH2, CH2CH2, CH>； = CH, C≡C, CH2O, OCH2, NR4CH2 and CH2NR4, - W represents a group R5, SR5, OR5 or NR5R6, - U represents a CH2 or NH group, - V represents C (O), - n represents 0, - R1 represents a hydrogen atom or a NR7R8 group, - R2 represents one of the following groups : NH2, NH (CH2) 3NMe2, NMe (CH2) 3NMe2, NO2, ** (See formula) ** or ** (See formula) ** - R3 represents H, - R4, R11 to R25 and R27 to R28 represent each, independently of each other, a hydrogen atom or a (C1-C6) alkyl group, -R5 and R6 each independently represent a hydrogen atom or a (C1-C6) alkyl, optionally substituted aryl group optionally substituted or benzyl, - R7 and R8 each independently represent a hydrogen atom or an optionally substituted (C1-C6) alkyl o
