CIAPETTI, PAOLA,CHERY-MOZZICONACCI, FLORENCE,WERMUTH, CAMILLE,ROPP, SANDRINE,MORICE, CHRISTOPHE,GIETHLEN, BRUNO,LEBLANC, FRANCOISE,SCHNEIDER, MARC
申请号：
ES09794051
公开号：
ES2380906T3
申请日:
2009.06.30
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
The compounds of formula (I): ** Formula ** in which: R1 and R2 form a 5- or 6-membered carbon cycle optionally substituted by a Ra group and / or by two Rb and R'b groups attached thereto carbon atom, Ra represents a hydrogen, halogen, linear or branched (C1-C6) alkyl, cycloalkyl (C3-C6), aryl (C6-C10), aralkyl (C7-C12), OH, (C1-C6) alkoxy linear or branched, aryl O- (C6-C10), aralkyl O- (C7-C12) or NRR '； R and R 'together represent a carbon chain (C3-C6) possibly interrupted by a heteroatom selected from N, O and S and optionally substituted by 1 or 2 linear or branched (C1-C6) alkyls； or R and R ', identical or different, represent hydrogen, linear or branched (C1-C6) alkyl, (C3-C6) cycloalkyl； or R represents hydrogen and R 'represents a 5- or 6-membered heterocycle containing 1 to 3 heteroatoms selected from N, O and S, optionally substituted by 1 or 2 linear or branched (C1-C6) alkyls； Rb and R'b, identical or different, represent hydrogen, linear or branched (C1-C6) alkyl, cycloalkyl (C3-C6), aryl (C6-C10) or aralkyl (C7-C12)； or Rb and R'b form a carbonyl； or R1 represents a CO-R'1 radical, in which R'1 represents a 5- or 6-membered aromatic heterocycle containing from 1 to 3 heteroatoms selected from N, O and S, optionally substituted by 1 or 2 alkyls ( C1-C6) linear or branched, and R2 represents hydrogen； or R1 represents a radical of the formula: in which Rc represents a linear or branched (C1-C6) alkyl, optionally substituted by a member of the group consisting of COOH, COORf, NH2, linear or branched NH- (C1-C6) alkyl , linear or branched N- (C1-C6) dialkyl and linear or branched NH-CO (C1-C6) alkyl, Rf represents a linear or branched (C1-C6) alkyl, Rd represents hydrogen or CO- (C1-C6) alkyl ) linear or branched and Re represents hydrogen, or Rc and Re form a pyrrolidine ring and Rd is defined as above, and R2 represents hydrogen； or R1 represents a radical of the formula: in which R "1 represents a linear or branched (C1-C6) alkyl substituted by COOH
