PAOLA CIAPETTI,FLORENCE CHERY-MOZZICONACCI,CAMILLE G. WERMUTH,SANDRINE ROPP,CHRISTOPHE MORICE,BRUNO GIETHLEN,FRANÇOISE LEBLANC,MARC SCHNEIDER
申请号：
HRP20120329
公开号：
HRP20120329T1
申请日:
2012.04.13
申请国别(地区):
HR
年份:
2012
代理人:
摘要：
Claim 1: the compounds of formula (1) wherein R1 and R2 are a carbon cycle of 5 or 6 members optionally substituted by one group or two groups ra and RB and R 'b attached to the same Carbon u00a0tomo ra represents Hydrogen, halogen, alkyl of C1 - 6 linear or branched cycloalkyl, C3 - 6 (C6, C7 aralquilo - 10, - 12, - 6, - linear or branched alkoxy C1 - C6, aryl or 10Aralquilo or C7 or NRR '12； R and R' together represent a carbon chain C3 6 possibly interrupted by a hetero u00a0tomo selected from N, o and S and optionally replaced by 1 or 2, linear or branched alkyl C1 - 6； R and R ', identical or different, represent Hydrogen, C1 - Rent 6 linear or branched.Cycloalkyl or C3 - 6； R represents Hydrogen and R 'represents one of five or six members Heterocycles containing 1 to 3 hetero u00a0tomos selected from N, o and S, optionally replaced by 1 or 2, linear or branched alkyl C1 - 6； RB and R' B, identical or different, represent Hydrogen, alkyl C1 - C3 6 linear or branched, cycloalkyl - 6Aryl C6 or C7 aralquilo 10 - 12； or RB and R 'b form a carbonyl； r1 represents a radical or co - R' r '1, where 1 represents a arom u00a0tico of five or six members Heterocycles containing 1 to 3 hetero u00a0tomos selected from N, o and S, optionally substituted 1 or 2 C1 - 6 Linear alkyl or RAM As,R1 and R2 represents Hydrogen； or represents a radical of formula (2) in which RC represents a linear or branched alkyl C1 - 6, optionally replaced by a member of the group of coorf COOH, NH2, NH, C1 - alkyl - 6 linear or branched, dialkyl N - linear or branched and C1 - 6 Rent n H - CO - C1 - 6 linear or branched alkyl, RF represents a linear or branched C1 - 6,RD represents Hydrogen or alkyl co C1 - 6 linear or branched and re represents Hydrogen, or RC and re form a pyrrolidine ring and Rd is defined as above, and R2 represents Hydrogen； r1 represents a radical of formula (3), in which R 1 represents a linear or branched alkyl C1 - their 6 Replace COOH, coorf, RG or corg, RF is defined
