CALDARELLI, Marina,CASUSCELLI, Francesco,DONATI, Daniele,MIRIZZI, Danilo,QUARTIERI, Francesca,SILVAGNI, Marco
申请号：
ES12700566
公开号：
ES2586588T3
申请日:
2012.01.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) ** Formula ** wherein: R 1 is hydrogen, halogen or a group selected from amino, linear or branched C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl and heterocyclyl alkyl； X is a single bond or a divalent radical selected from -NR'-, -CONR'-, -NH-CO-NH-, -O-, -S-, -SO2- and -OSO2-, where R 'is hydrogen or a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl and heterocyclylalkyl； one of Y and Z is nitrogen and the other is N-R3, where R3 is hydrogen or a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl and heterocyclylalkyl or is a group - (CH2) n-, where n is 2 or 3, forming a ring with R2, or Y is oxygen and Z is nitrogen, or Y is nitrogen and Z is oxygen； R2 is a group selected from -NR "R" ', -N (OR "') R" and OR ", where R" and R '"are each independently hydrogen or a group selected from linear C1-C6 alkyl or branched, C3-C7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl and heterocyclylalkyl or, together with the nitrogen atom to which they are attached, R "and R" can form a 5- to 6-membered heteroaryl or heterocyclyl group, which optionally it contains an additional heteroatom selected from N, O and S； or a pharmaceutically acceptable salt thereof, where any of the above groups R1, R2, R3, R ', R "and R"' may be optionally substituted, in any of their free positions, with one or more groups, for example from 1 to 6 groups, independently selected from: halogen, nitro, oxo (>； = O), cyano, C1-C6 alkyl, perfluorinated alkyl, perfluorinated alkoxy, alkenyl, alkynyl, hydroxyalkyl, aryl, arylalkyl, heterocyclyl, C3-C7 cycloalkyl, hydroxy, alkoxy, aryloxy, heterocyclyl oxy, methylenedioxy, alkylcarbonyloxy, arylcarbonyloxy, cycloalkenyloxy, heterocyclylcarbonyloxy, alkylideneaminooxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, cycloalkyloxycarbonyl, heterocyclyl
