Compound of formula (I) ** Formula ** its pharmaceutically acceptable salts and its stereoisomers, tautomers, hydrates and solvates； wherein, when Y is NR4, O, S or SO2, m is 1 to 2 and when Y is C (R5) (R6), m is 1 to 4； n is from 1 to 6； P is -OH, -OR7, -NH2, -NHR7, -NR7R7 ', -NHSO2R7, -NHCOR7, -NHOH or -NHOR7； X is -OH, -OR7, -SR7, -SOR7, -SO2R7, -NHR7 or -NR7R7 '； Z is S or O； R is hydrogen, linear or branched C1-C8 alkyl, -C1-C8-aryl alkyl or -C1-C8 alkyl-heteroaryl； R1 and R2 are independently selected from hydrogen, -C1-C8 linear or branched alkyl, -C3-C7 cycloalkyl, aryl, heteroaryl, -CH2-aryl and -CH2-heteroaryl, or R1 and R2 can be linked together to form a ring 3-6 members monocyclic or 9-12 members bicyclic； R together with any of R1 or R2 of the adjacent carbon atom may form a 3-6 membered monocyclic heterocyclyl or 8-11 membered bicyclic heterocyclyl ring； R3 and R3 'at each occurrence are independently selected from hydrogen, linear or branched C1-C8 alkyl, C1-C5 alkoxy and halo； R3 and R3 'may also be present in a gem-di-halo, gem-di-alkyl or spirocycloalkyl arrangement； R4 is selected from the group consisting of hydrogen, linear or branched C1-C8 alkyl, C3-C7 cycloalkyl, aryl, heteroaryl, -C1-C8-alkyl-aryl, -C1-C8-heteroaryl alkyl, -C1-C2-heterocyclyl alkyl , -C (O) R8, -C (O) OR8, -C (O) NR8R9, -C (S) NR8R9 and -SO2R8, in which the aryl and heteroaryl radicals are optionally substituted with one or more substituents selected from the group consisting of -C1-C8 alkyl, -C3-C7 cycloalkyl, heterocyclyl, aryl, heteroaryl, -OH, -alkoxy, halo, CN, -CF3, -OCF3, -O-aryl, -SO2-C1-C8 alkyl , -SO2-aryl, -NH2, -NHR10, -NR10R10 ', -NH-CO-C1-C8-alkyl, -NH-SO2-C1-C8-alkyl, -NH-SO2-aryl, -COOH, -C (O ) NH-alkyl, -CONH-aryl, -CONH-heteroaryl, -C (O) O-C1-C8 alkyl, -C (O) O-aryl, -SO2NH-C1-C8 alkyl, -SO2NH-aryl and - SO2NH-heteroaryl； R5 and R6 are independently selected from the group consisting of hydrogen, linear or branched C1-C8 alkyl, C3-C7 cycloalkyl, aryl, h
