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COMBINING ORTHOGONAL CHEMISTRIES FOR PREPARATION OF MULTIPLEXED NANOPARTICLES
专利权人:
Verily Life Sciences LLC
发明人:
Nicole Peck,Zhan Wang
申请号:
US16281991
公开号:
US20190254973A1
申请日:
2019.02.21
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Disclosed herein is a particle comprising a first effector element covalently bonded to a nanoparticle via a first orthogonal moiety and a second effector element covalently bonded to the nanoparticle via a second orthogonal moiety, wherein the first orthogonal moiety and the second orthogonal moiety have different chemical structures. The first effector element and the second effector element may be, for example, a targeting agent, a therapeutic agent, and a diagnostic agent. In certain embodiments, the nanoparticle is a liposome. Methods for preparing functionalized nanoparticles, including functionalized liposomes, are also described.
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